Colistin

Colistin – High-Purity Polymyxin E Antibiotic for Veterinary and Pharmaceutical Applications

Xi'an Linnas Biotech Co., Ltd. specializes in manufacturing pharmaceutical-grade Colistin (Polymyxin E) Having a 99% purity criterion, guaranteeing excellent quality for vital infection control and veterinary treatments. To ensure consistent performance from batch to batch, our product is subjected to a thorough HPLC component composition analysis and complies with ISO 9001 requirements. Our product comes in drums that weigh 20 kg, 25 kg, or 50 kg and is sent within three days after payment.It's in the form of a white crystalline powder.It works quickly to kill bacteria that are resistant to many drugs, especially Gram-negative bacteria.It's commonly used to treat infections in pigs, chickens, and fish.Linnas guarantees that the product has more than 19,000 IU/mg of potency and controlled moisture levels.

What Is Colistin and Why It Matters

Our product, also known as Polymyxin E, is a type of antibiotic made from a cyclic polypeptide that is produced when Bacillus polymyxa is grown through fermentation.It works by binding to the lipopolysaccharide layer of the outer membrane of Gram-negative bacteria, which causes the membrane to break down and the bacteria to die.

This antibiotic is used to treat serious diseases in veterinary medicine caused by bacteria that are resistant to many other antibiotics, such as Pseudomonas aeruginosa and carbapenem-resistant Enterobacteriaceae.
Even though there is growing resistance to traditional antibiotics, our product remains an important treatment for severe intestinal infections in cattle and fish farming.

Its targeted action helps kill harmful bacteria without harming the beneficial bacteria in the gut. It is quite useful for treating salmonellosis and enteric colibacillosis in industrial animals because of its accuracy.

Key Applications in Veterinary and Pharmaceutical Sectors

Veterinary Gastrointestinal Therapeutics

Colistin Sulfate is formulated as oral solutions or premixes for livestock. It works well to fight intestinal infections in chickens, pigs, and young cows by working directly in the digestive system.It stays in the lower part of the intestine and doesn't enter the bloodstream because it is strong in the acidic environment of the stomach.In farms, this targeted action helps animals live longer by reducing harmful bacteria and stopping blood infections.

Topical and Specialized Medical Use

The substance is added to ophthalmic solutions and otic drops because of its surfactant qualities. For increased effectiveness, these formulations are frequently used in conjunction with corticosteroids to treat external infections such as otitis externa.

It reduces mortality during intense farming cycles in aquaculture by controlling bacterial breakouts in fish and shrimp.

Technical Specifications and Quality Parameters

Our pharmaceutical-grade product meets stringent European Pharmacopoeia (EP) and United States Pharmacopeia (USP) standards.

The controlled hygroscopic nature requires storage at 2°C–8°C in airtight containers. This preserves polypeptide chain integrity and maintains antimicrobial activity throughout shelf life.

Why Choose Linnas for Your Colistin Supply

Superior Production and Quality Control

Our advanced analytical tools and automated production lines guaranty constant product quality. Each batch is subjected to purity testing, microbiological potency studies, and thorough HPLC component analysis.

To keep things safe and effective, we carefully watch the amounts of Polymyxin E1 and E2.This helps us get the best treatment results while lowering the chance of kidney damage.

International Compliance and Certifications

Our products meet international rules because they have ISO 9001 certification and follow Halal, Kosher, and organic standards when needed.This makes it easier for customers in Europe, North America, and Asia to import our products.

Adaptable OEM and ODM Services

To aid in the growth of your brand, we offer private labeling, specialized formulas, and packaging options. Our technical staff works with you to create products that meet certain market demands.

Dependable Supply Chain and Quick Delivery

We help speed up your procurement process by offering fast stock availability and three-day delivery.Our logistics system keeps your products safe by using moisture-resistant packaging during transportation.

Product Packaging Options

We provide adaptable packaging to accommodate different order quantities:

• 20 kilogram drums: Typical industrial packaging
• 25 kilogram drums: Designed for medium-sized businesses
• 50 kilogram drums: economical for high volume needs

Product stability during international shipping is ensured by the use of tamper-evident seals and moisture-resistant materials in all packing.

Frequently Asked Questions About Colistin

Q: What distinguishes Colistimethate Sodium from Colistin Sulfate?

A: The stable cationic form used in topical and oral veterinary treatments is colistin sulfate. In order to lessen injection site toxicity, Colistimethate Sodium is a prodrug version used parenterally in human medicine.

Q: What is the best way to keep this raw material?

A: Keep in light-resistant, sealed containers between 2°C and 8°C. It is susceptible to moisture due to its hygroscopic nature, which can reduce antibacterial action.

Q: Is it compatible with other antibiotics?

A: Some medications are physically incompatible. Prior to developing combination formulations, stability tests are crucial. For unique applications, speak with your formulation specialist.

Q: Which quality testing do you carry out?

A: To guaranty pharmaceutical-grade quality, we do optical rotation measurements, loss on drying testing, microbiological potency studies against reference strains, and HPLC component composition analysis.

Q: Is it possible to get a free sample?

A: Before placing large orders, we do offer samples for quality assessment. This enables you to confirm that the product is appropriate for your particular use.

Contact Us for Professional Support

Ready to use the Colistin to source high-purity pharmaceutical-grade materials for your veterinary or therapeutic applications? Email: cathy@linnas.com.cn.